My Academic Interest In Biochemistry
My interest in Biochemistry stems from my curiosity about the complexity of our chemical make-up. Reading ‘The Selfish Gene’ by Richard Dawkins about the deterministic nature of genes for survival taught me how our behaviour is a product of a lifetime of gene-environment interactions. In an epigenetics lecture, I was equally fascinated to discover how gut microbes can influence the way our DNA is packaged later in life. I’m struck by how the intricate components of our body are highly interdependent with each other; the work of evolution is truly unmatched by any machine. As my studies advance, my understanding of what defines us is continually challenged, and I hope I can uncover answers to this fundamental question.
Being involved in the Wellcome Trust Genome Decoder project on Trichuris Trichiura (the human whipworm) gave me the opportunity to explore my enthusiasm for the subject in a productive way. Using the software APOLLO to decide on the best gene predictions and edit the genes, I developed my critical thinking and analytical ability. I also began to appreciate the rigorous assessment and discipline required in biochemical research. Furthermore, it’s been exciting to read about CRISPR in New Scientist as it enables me to appreciate how the cell’s own DNA repair mechanism can be pivotal in providing treatment for all inherited diseases. However, I understand success stories of the lab are only a small step in the right direction towards benefit in real life, and we must be careful not to forget the ethical considerations. ‘Bad Pharma’ by Ben Goldacre explores the ethics of drug research in particular and the validity of published trials. This prompts me to always question my work especially during data analysis in my chemistry lessons.
Attending a HE+ Biology lecture on Alzheimer’s made me realise the importance of structure in biological molecules like proteins. As beta-amyloid plaques and neurofibrillary tangles consisted of tau accumulate in the brain, it translates to an increasingly difficult battle for independence for the patient. I witnessed this first-hand during work experience with the Frailty Interface Team. Working at a play scheme for disabled youth every Saturday has been hugely rewarding. I enjoy observing and interpreting an individual’s behaviour and adapting the way I interact with them. Working with a boy with global development delay also led me to self-teach basic Makaton and BSL. Assisting with feeding and toileting gave me insight into the realities of debilitating disorders like cerebral palsy and Angelman syndrome. This allowed me to recognise the benefit medical research like the Toby trial can bring, which uses the concept of whole body hypothermia to treat perinatal asphyxial encephalopathy.
Volunteering in a homeless shelter for 5 months enabled me to interact with a variety of people, preparing me well for university. In addition, giving presentations on self-researched diseases in Anatomy and Physiology club has pushed me to explain complicated ideas in a more understandable and relatable way. I improved my skill of answering questions tactfully, but the gaps in my knowledge were highlighted, emphasising the importance of continuous learning in an ever-changing profession. I am working towards Grade 6 piano. Learning new pieces of music has taught me the value of practice and patience as well as good time management skills. I applied these skills during my RAF logistics work experience, which I was awarded the Silver CREST Award and Industrial Cadet Level 2 for. I improved my flexibility and used my own initiative in tasks like planning a humanitarian aid operation or leading a team and building a small-scale pipeline. Furthermore, completing DofE was a test of my perseverance and teamwork.
This summer, I plan to teach English in China. I have only touched the surface of biochemistry, but I have realised the remarkable power it has given us to continually redefine the limits of tomorrow’s medicine. I am confident I can face the challenges of university and beyond with commitment and determination to succeed.
